| 货号 | 20376-500mg |
| 描述 | D-Glucose-6-phosphate is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or by the conversion of glucose-1-phosphate by phosphoglucomutase, which is the first step of glycogen synthesis.1 It is stored as glycogen when blood glucose levels are high. Disruption of D-glucose-6-phosphate activity leads to glycogen storage disease type I or von Gierke’s disease, a group of inherited metabolic diseases characterized by severe hypoglycemia, growth retardation, and hepatomegaly, due to accumulation of glycogen and fat in the liver.2,3 D-Glucose-6-phosphate is also the starting molecule of both glycolysis and the pentose phosphate pathways.4 Because cancer cells adopt glycolysis as a major source of metabolic energy production, and the pentose phosphate pathway plays a role in helping glycolytic cancer cells to meet their anabolic demands, this compound can be used to study the progression of this process.5 |
| 别名 | G6P;Sodium Glucose-6-Phosphate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Berg, J.M.,Tymoczko, J.L., and Stryer, L. Biochemistry. 5th Edition, (2002). 2.Cappellini, M.D., and Fiorelli, G. Glucose-6-phosphate dehydrogenase deficiency. Lancet 371(9606), 64-74 (2008). 3.Beutler, E. Glucose-6-phosphate dehydrogenase deficiency: A historical perspective. Blood 111(1), 16-24 (2008). 4.Gumaa, K.A., and McLean, P. The pentose phosphate pathway of glucose metabolism: Enzyme profiles and transient and steady-state content of intermediates of alternative pathways of glucose metabolism in Krebs ascites cells. Biochemistry Journal 115(5), 1009-1029 (1969). 5.Patra, K.C., and Hay, N. The pentose phosphate pathway and cancer. Trends Biochem. Sci. 39(8), 347-354 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 282.1 |
| 分子式 | C6H12O9P • Na |
| CAS号 | 54010-71-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |