Ezutromid
货号：
20309-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20309-1mg |
| 描述 | Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and protein.1 Through this action, ezutromid increases muscle function in dystrophin-deficient mdx mice, a mouse model of muscular dystrophy.1 A double-blind, placebo-controlled Phase I study demonstrated that ezutromid is safe and well tolerated in healthy volunteers.2 |
| 别名 | BMN 195;SMT-C1100;VOX-C1100; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tinsley, J.M.,Fairclough, R.J.,Storer, R., et al. Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse. PLoS One 6(5), e19189 (2011).
2.Tinsley, J.,Robinson, N., and Davies, K.E. Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers. J. Clin. Pharmacol. 55(6), 698-707 (2015).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.4 |
| 分子式 | C19H15NO3S |
| CAS号 | 945531-77-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
