GSK481
货号：
20308-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20308-1mg |
| 描述 | GSK481 is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM.1 It is selective for RIP1 over a panel of over 450 other kinases, including RIP3.2,1 GSK481 inhibits RIP1 from human and cynomolgus monkey but is at least 100-fold less potent against non-primate RIP1.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Harris, P.A.,King, B.W.,Bandyopadhyay, D., et al. DNA-encoded library screening identifies benzo[b][1,4]oxazepin-4-ones as highly potent and monoselective receptor interacting protein 1 kinase inhibitors. J. Med. Chem. 59(5), 2163-2178 (2016).
2.Geserick, P.,Wang, J.,Schilling, R., et al. Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis. 6, e1884 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.4 |
| 分子式 | C21H19N3O4 |
| CAS号 | 1622849-58-4 |
| 稳定性 | ≥ 2 years |
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