Terfenadine
货号：
20305-500mg 基本售价：
350.0 元 规格：
500 mg
产品信息
概述| 货号 | 20305-500mg |
| 描述 | Terfenadine is a selective histamine H1-receptor antagonist with anti-allergic effects that lacks central nervous system depressant activity.1 It is a prodrug that undergoes extensive first-pass hepatic metabolism by the cytochrome P450 enzyme CYP3A4 to its pharmacologically active metabolite fexofenadine (Item No. 18191).2 Terfenadine is reported to be cardiotoxic, inducing QT interval prolongation by blocking cardiac potassium channels.3 |
| 别名 | MDL 9918;NSC 665802;(±)-Terfenadine;DL-Terfenadine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baroody, F.M., and Naclerio, R.M. Antiallergic effects of H1-receptor antagonists. Allergy 55(Suppl 64), 17-27 (2000).
2.Amichai, B.,Grunwald, M.H., and Brenner, L. Fexofenadine hydrochloride--a new anti-histaminic drug. Isr. Med. Assoc. J. 3(3), 207-209 (2001).
3.Zünkler, B.J.,Kühne, S.,Rustenbeck, I., et al. Mechanism of terfenadine block of ATP-sensitive K+ channels. Br. J. Pharmacol. 130(7), 1571-1574 (2000).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 471.7 |
| 分子式 | C32H41NO2 |
| CAS号 | 50679-08-8 |
| 稳定性 | ≥ 2 years |
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