Hyocholic Acid
货号：
20293-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 20293-500ug |
| 描述 | Hyocholic acid is a natural bile acid found in mammals. It is a trihydroxy-5β-cholanic acid in which the three hydroxy moieties are located at the 3α, 6α, and 7α positions. Hyocholic acid is an important trihydroxy bile acid in mice, rats, pigs, and certain other animals, whereas cholic acid (Item No. 20250) is the primary bile acid in humans.1 Hyocholic acid included in chow for mice is converted by gut microflora primarily to taurohyocholate and, to a lesser extent, taurocholic acid (Item No. 16215) and tauro-β-muricholic acid (Item No. 20289).2 Hyocholic acid is considered a hydrophilic bile acid that has low toxicity against human hepatoma HepG2 cells.2,3 |
| 别名 | HCA;γ-MCA;γ-Muricholic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lundell, K., and Wikvall, K. Species-specific and age-dependent bile acid composition: Aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis. Curr. Drug Metab. 9(4), 323-331 (2008).
2.Wang, D.Q.-H.,Tazuma, S.,Cohen, D.E., et al. Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: Studies in the gallstone-susceptible mouse. Am. J. Physiol Gastrointest. Liver Physiol. 285(3), G494-G502 (2003).
3.Perreault, M.,Bialek, A.,Trottier, J., et al. Role of glucuronidation for hepatic detoxification and urinary elimination of toxic bile acids during biliary obstruction. PLoS One 8(11), e80994 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 408.6 |
| 分子式 | C24H40O5 |
| CAS号 | 547-75-1 |
| 稳定性 | ≥ 2 years |
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