NPC-15437 (hydrochloride)
货号：
20212-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 20212-500ug |
| 描述 | NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 µM).1 It competitively inhibits phorbol ester- (Ki = 5 µM) and phosphatidylserine-induced (Ki = 12 µM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sullivan, J.P.,Connor, J.R.,Shearer, B.G., et al. 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol. Pharmacol. 41(1), 38-44 (1992).
2.Mathis, C.,Lehmann, J., and Ungerer, A. The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur. J. Pharmacol. 220(1), 107-110 (1992).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 511.6 |
| 分子式 | C25H50N4O2 • 2HCl |
| CAS号 | 141774-20-1 |
| 稳定性 | ≥ 2 years |
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