BML-278
货号：
20209-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20209-1mg |
| 描述 | BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.1 It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 µM, respectively).1 BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA (Item No. 10009929), a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mai, A.,Valente, S.,Meade, S., et al. Study of 1,4-dihydropyridine structural scaffold: Discovery of novel sirtuin activators and inhibitors. J. Med. Chem. 52(17), 5496-5504 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 391.5 |
| 分子式 | C24H25NO4 |
| CAS号 | 120533-76-8 |
| 稳定性 | ≥ 2 years |
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