Tosyl Phenylalanyl Chloromethyl Ketone
货号：
20166-100mg 基本售价：
350.0 元 规格：
100 mg
产品信息
概述| 货号 | 20166-100mg |
| 描述 | Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis.1 It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2.2 TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.3 |
| 别名 | Nα-Tosyl-L-Phenylalanine Chloromethyl Ketone;TPCK; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Blair, T.T., and Marini, M.A. A reexamination of the reaction of TPCK with α-chymotrypsin. FEBS Lett. 20(1), 41-43 (1972).
2.Anjum, R.,Pae, E.,Blenis, J., et al. TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. FEBS Lett. 586(19), 3471-3476 (2012).
3.Gillibert, M.,Dehry, Z.,Terrier, M., et al. Another biological effect of tosylphenylalanylchloromethane (TPCK): It prevents p47phox phosphorylation and translocation upon neutrophil stimulation. Biochem J. 386(Pt 3), 549-556 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351.8 |
| 分子式 | C17H18ClNO3S |
| CAS号 | 402-71-1 |
| 稳定性 | ≥ 2 years |
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