FPL 64176
货号：
20122-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20122-1mg |
| 描述 | FPL 64176 is a nondihydropyridine that activates L-type Ca2+ channels with an EC50 value of 16 nM.1,2 It prolongs action potential duration and increases contractility in guinea pig atria preparations with an EC50 value of 49 nM.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zheng, W.,Rampe, D., and Triggle, D.J. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol.Pharmacol. 40(5), 734-741 (1991).
2.Baxter, A.J.G.,Dixon, J.,Ince, F., et al. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: The first examples of a new class of calcium channel activator. J.Med.Chem. 36(19), 2739-2744 (1993).
3.Rampe, D.,Anderson, B.,Rapien-Pryor, V., et al. Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176. J.Pharmacol.Exp.Ther. 265(3), 1125-1130 (1993).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 347.4 |
| 分子式 | C22H21NO3 |
| CAS号 | 120934-96-5 |
| 稳定性 | ≥ 2 years |
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