K-Ras(G12C) Inhibitor 12
货号：
20118-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20118-1mg |
| 描述 | K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions.1 K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ostrem, J.M.,Peters, U.,Sos, M.L., et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503(7477), 548-551 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 449.7 |
| 分子式 | C15H17ClIN3O3 |
| CAS号 | 1469337-95-8 |
| 稳定性 | ≥ 2 years |
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