COTI-2
货号：
20031-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20031-1mg |
| 描述 | COTI-2 is an orally available thiosemicarbazone that activates mutant forms of p53. It induces apoptosis in a wide variety of human tumor cells in culture, inhibits the proliferation of colorectal cancer cell lines more effectively than cetuximab and erlotinib (Item No. 10483), and is active against human glioblastoma cell lines at nanomolar concentrations.1 COTI-2 functions well in vivo, inhibiting the growth of HT-29 colorectal, SHP-77 small cell lung cancer, and OVCAR-3 ovarian carcinoma xenograft cells in mice with minimal toxicity.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Salim, K.Y.,Vareki, S.M.,Danter, W.R., et al. COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo. Oncotarget 7(27), (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% (E/Z mixture) |
| 计算分子量 | 366.5 |
| 分子式 | C19H22N6S |
| CAS号 | 1039455-84-9 |
| 稳定性 | ≥ 2 years |
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