Ro 4929097
货号：
19996-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 19996-500ug |
| 描述 | Ro 4929097 is a potent inhibitor of γ-secretase (IC50 = 4 nM) that blocks both Aβ40 and Notch processing (IC50s = 14 and 5 nM, respectively).1 It displays greater than 100-fold selectivity for γ-secretase over a panel of 75 other enzymes, receptors, and ion channels. Ro 4929097 does not block tumor cell growth or induce apoptosis but instead produces a less transformed, flattened, slower-growing phenotype.1 It is orally active against cancer xenograft models, altering gene expression related to angiogenesis and cell differentiation.1 Ro 4929097 also reduces tumor initiating potential of melanoma cells in vivo by blocking Notch-dependent gene expression.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Luistro, L.,He, W.,Smith, M., et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res. 69(19), 7620-7680 (2009).
2.Huynh, C.,Poliseno, L.,Segura, M.F., et al. The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma. PLoS One 6(9), (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469.4 |
| 分子式 | C22H20F5N3O3 |
| CAS号 | 847925-91-1 |
| 稳定性 | ≥ 2 years |
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