CCT007093
货号：
19992-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19992-1mg |
| 描述 | CCT007093 is an inhibitor of protein phosphatase 1D (PPM1D, also known as PP2Cδ and WIP1; IC50 = 8.4 µM), which is encoded by a putative oncogene that is amplified in multiple cancer types.1 It does not inhibit PPM1A. CCT007093 selectively inhibits the growth of cancer cells that overexpress PPM1D, including MCF-7, KPL-1, and MCF-3B cells, as well as certain ovarian clear cell carcinoma cells.1,2 CCT007093 has been used to elucidate the mechanism by which PPM1D drives growth in medulloblastoma cells.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rayter, S.,Elliott, R.,Travers, J., et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene 27(8), 1036-1044 (2008).
2.Tan, D.S.P.,Labmbros, M.B.K.,Rayter, S., et al. PPM1D is a potential therapeutic target in ovarian clear cell carcinomas. Clin. Cancer. Res 15(7), 2269-2280 (2009).
3.Buss, M.C.,Read, T.-A.,Schniederjan, M.J., et al. HDM2 promotes WIP1-mediated medulloblastoma growth. Neuro. Oncol. 14(4), 440-458 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 272.4 |
| 分子式 | C15H12OS2 |
| CAS号 | 176957-55-4 |
| 稳定性 | ≥ 2 years |
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