| 货号 | 19988-500ug |
| 描述 | (S)-(−)-BAY-K-8644 is an activator of voltage-sensitive L-type calcium channels.1,2 It demonstrates vasoconstrictive and positive inotropic effects in vivo as well as behavioral effects, including deficits to motor function.3,4 When combined with BIX01294 (Item No. 13124), (S)-(−)-BAY-K-8644 can enable reprogramming of mouse embryonic fibroblasts after transduction with Oct4/Klf4.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ravens, U., and Schöpper, H.P. Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn-Schmiedebergs Archives of Pharmacology 341(3), 232-239 (1990). 2.Artigas, P.,Ferreira, G.,Reyes, N., et al. Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes. Journal of Membrane Biology 193(3), 215-227 (2003). 3.Franckowiak, G.,Bechem, M.,Schramm, M., et al. The optical isomers of the 1,4-dihydropyridine Bay K 8644 show opposite effects on Ca channels. European Journal of Pharmacology 114(2), 223-226 (1985). 4.ONeill, S.K., and Bolger, G.T. Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Research Bulletin 21(6), 865-872 (1988). 5.Shi, Y.,Desponts, C.,Do, J.T., et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5), 568-574 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.3 |
| 分子式 | C16H15F3N2O4 |
| CAS号 | 98625-26-4 |
| 稳定性 | ≥ 2 years |
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