TCS ERK 11e
货号：
19932-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19932-1mg |
| 描述 | TCS ERK 11e is an orally bioavailable inhibitor of extracellular signal-related kinase 2 (ERK2; Ki<2 nM).1 It is over 200-fold selective against related kinases GSK3, Aurora Kinase A, and Cdk2 with Ki values of 395, 540, and 852 nM, respectively.1 TCS ERK 11e has been shown to block the proliferation of HT29 cells with an IC50 value of 48 nM.1 |
| 别名 | TCS Extracellular Signal-Related Kinase 11e;VX-11e; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Aronov, A.M.,Tang, Q.,Martinez-Botella, G., et al. Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem. 52(20), 6362-6368 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 500.4 |
| 分子式 | C24H20Cl2FN5O2 |
| CAS号 | 896720-20-0 |
| 稳定性 | ≥ 2 years |
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