AT-406
货号：
19929-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 19929-500ug |
| 描述 | AT-406 is an orally bioavailable Smac/DIABLO mimetic and antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to XIAP, cIAP1, and cIAP2 proteins with Ki values of 66.4, 1.9, and 5.1 nM, respectively.1 It has been shown to inhibit cancer cell growth in various human cancer cell lines and to induce apoptosis in xenograft tumors in mice.1,2 |
| 别名 | SM-406; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cai, Q.,Sun, H.,Peng, Y., et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J.Med.Chem. 54(8), 2714-2726 (2011).
2.Brunckhorst, M.K.,Lerner, D.,Wang, S., et al. AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer. Cancer Biol.Ther. 13(9), 804-811 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 561.7 |
| 分子式 | C32H43N5O4 |
| CAS号 | 1071992-99-8 |
| 稳定性 | ≥ 2 years |
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