NSC 59984
货号：
19919-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19919-1mg |
| 描述 | NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells.1 It is reported to induce cell death in colon cancer cells (EC50 = 8.38 µM in p53-null HCT116 cells) without evident toxicity toward normal cells.1 NSC 59984 has been shown to induce p53 mutant protein degradation via MDM2-mediated ubiquitination.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, S.,Zhou, L.,Hong, B., et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 75(18), 3842-3852 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 265.3 |
| 分子式 | C12H15N3O4 |
| CAS号 | 803647-40-7 |
| 稳定性 | ≥ 2 years |
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