| 货号 | 19916-1mg |
| 描述 | MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKε, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs; IC50s = 250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively).1,2,3,4 MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages.1,3 Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clark, K.,Peggie, M.,Plater, L., et al. Novel cross-talk within the IKK family controls innate immunity. Biochem. J. 434(1), 93-104 (2011). 2.Clark, K.,Takeuchi, O.,Akira, S., et al. The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 108(41), 17093-17098 (2011). 3.Clark, K.,MacKenzie, K.F.,Petkevicius, K., et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proceedings of the National Academy of Sciences of the United States of America 109(42), 16986-16991 (2012). 4.Petherick, K.J.,Conway, O.J.L.,Mpamhanga, C., et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J. Biol. Chem. 290(18), 11376-11383 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 464.6 |
| 分子式 | C26H36N6O2 |
| CAS号 | 1190378-57-4 |
| 稳定性 | ≥ 2 years |
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