LJH685
货号：
19913-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19913-1mg |
| 描述 | LJH685 is an inhibitor of p90 ribosomal S6 kinases (RSKs, also known as MAP kinase-activated protein kinases, or MAPKAPKs) that inhibits RSK1, 2, and 3 in vitro with IC50 values of 6, 5, and 4 nM, respectively.1 It is selective for RSKs over a panel of 96 other kinases. LJH685 blocks RSK activity in cells, preventing phosphorylation of y-box-binding protein 1 on Ser102.1 The inhibition of RSK activity correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines, but only in an anchorage-independent growth setting.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Aronchik, I.,Appleton, B.A.,Basham, S.E., et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol. Cancer Res. 12(5), 803-812 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 381.4 |
| 分子式 | C22H21F2N3O |
| CAS号 | 1627710-50-2 |
| 稳定性 | ≥ 2 years |
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