Uprosertib
货号：
19904-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19904-1mg |
| 描述 | Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).1 Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation viaPI3K/PTEN mutation or loss.2 It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SK-OV-3 ovarian tumor xenografts.2 |
| 别名 | GSK795;GSK2141795; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pachl, F.,Plattner, P.,Ruprecht, B., et al. Characterization of a chemical affinity probe targeting Akt kinases. J. Proteome Res. 12(8), 3792-3800 (2013).
2.Dumble, M.,Crouthamel, M.C.,Zhang, S.Y., et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One 9(6), (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429.2 |
| 分子式 | C18H16Cl2F2N4O2 |
| CAS号 | 1047634-65-0 |
| 稳定性 | ≥ 2 years |
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