WZB117
货号：
19900-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19900-1mg |
| 描述 | WZB117 is an irreversible inhibitor of glucose transporter 1 (Glut1) that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM), reducing extracellular lactate and intracellular ATP levels.1 It inhibits cancer cell proliferation (IC50s = 5-10 µM), resulting in cell cycle arrest, senescence, and necrosis or apoptosis.1,2 These effects are enhanced by the anticancer drugs cisplatin (Item No. 13119) and paclitaxel (Item No. 10461). WZB117, given intraperitoneally at 10 mg/kg, significantly reduces tumor size in mice, with only small reductions in body weight and leukocyte count.1 WZB117 also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.3 |
| 别名 | Glucose Transporter Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, Y.,Cao, Y.,Zhang, W., et al. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol. Cancer Ther. 11(8), 1672-1682 (2012).
2.Xintaropoulou, C.,Ward, C.,Wise, A., et al. A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models. Oncotarget 6(28), 25677-25695 (2015).
3.Shibuya, K.,Okada, M.,Suzuki, S., et al. Targeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells. Oncotarget 6(2), 651-661 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.3 |
| 分子式 | C20H13FO6 |
| CAS号 | 1223397-11-2 |
| 稳定性 | ≥ 2 years |
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