Pomalidomide
货号：
19877-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19877-1mg |
| 描述 | Pomalidomide is an analog of thalidomide (Item No. 14610) that directly targets the E3 ligase protein cereblon, preventing cereblon autoubiquitination activity.1,2 By this mechanism, pomalidomide has been shown to exert antiproliferative, antiangiogenic, and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8.2,3 |
| 别名 | CC-4047;3-amino Thalidomide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lopez-Girona, A.,Mendy, D.,Miller, K., et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia 26(11), 2326-2335 (2012).
2.Zhu, Y.X.,Kortuem, K.M., and Stewart, A.K. Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leukemia and Lymphoma 54(4), 683-687 (2013).
3.Latif, T.,Chauhan, N.,Khan, R., et al. Thalidomide and its analogues in the treatment of multiple myeloma. Exp.Hermatol.Oncol. 1(1), 27 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 273.2 |
| 分子式 | C13H11N3O4 |
| CAS号 | 19171-19-8 |
| 稳定性 | ≥ 2 years |
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