Epacadostat
货号：
19875-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19875-1mg |
| 描述 | Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO).1 It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells.1 Epacadostat can also inhibit tumor growth in tumor-bearing mice in a lymphocyte-dependent manner.1 |
| 别名 | INCB024360; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, X.,Shin, N.,Koblish, H.K., et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood 115(17), 3520-3530 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 438.2 |
| 分子式 | C11H13BrFN7O4S |
| CAS号 | 1204669-58-8 |
| 稳定性 | ≥ 2 years |
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