Yohimbine (hydrochloride)
货号：
19869-500mg 基本售价：
350.0 元 规格：
500 mg
产品信息
概述| 货号 | 19869-500mg |
| 描述 | Yohimbine is a natural alkaloid that has highest affinity for α2-adrenergic receptors (pKis = 8.2, 8.7, and 9.6 for human α2A, α2B, and α2C, respectively), with antagonist activity at these receptors.1,2 It less potently antagonizes serotonin 5-HT1 receptors (pKis = 7.3, 6.8, and 7.6 for human HT1A, HT1B, and HT1D, respectively) and α1-adrenergic receptors (pKis = 6.7, 6.8, and 6.8 for human α1A, α1B, and α1D, respectively).1 Yohimbine is used in veterinary medicine to reverse the sedative effects of α2-agonists. |
| 别名 | NIH 9689;NSC 19509;Yohimbe; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Millan, M.J.,Newman-Tancredi, A.,Audinot, V., et al. Agonist and antagonist actions of yohimbine as compared to fluparoxan at α2-adrenergic receptors (AR)s, serotonin (5-HT)1A, 5-HT1B, 5-HT1D and dopamine D2 and D3 receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse 35(2), 79-95 (2000).
2.Schwartz, D.D., and Clark, T.P. Selectivity of atipamezole, yohimbine and tolazoline for alpha-2 adrenergic receptor subtypes: Implications for clinical reversal of alpha-2 adrenergic receptor mediated sedation in sheep. J. Vet. Pharmacol. Ther. 21(5), 342-347 (1998).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.9 |
| 分子式 | C21H26N2O3 • HCl |
| CAS号 | 65-19-0 |
| 稳定性 | ≥ 2 years |
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