Isoimperatorin
货号：
19851-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 19851-5mg |
| 描述 | Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity.1,2 Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B1 (Item No. 11293) to reactive metabolites.2,3 Isoimperatorin also induces the expression of glutathione S-transferase α by activating Nrf2.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cai, Y.,Bennett, D.,Nair, R.V., et al. Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkylase by naturally occurring coumarins. Chem. Res. Toxicol. 6(6), 872-879 (1993).
2.Cai, Y.,Baer-Dubowska, W.,Ashwood-Smith, M., et al. Inhibitory effects of naturally occurring coumarins on the metabolic activation of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in cultured mouse keratinocytes. Carcinogenesis 18(1), 215-222 (1997).
3.Pokaharel, Y.R.,Han, E.H.,Kim, J.Y., et al. Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: Bifunctional effects on glutathione S-transferase and CYP1A. Carcinogenesis 27(12), 2483-2490 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 270.3 |
| 分子式 | C16H14O4 |
| CAS号 | 482-45-1 |
| 稳定性 | ≥ 2 years |
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