KIN59
货号：
19833-10mg 基本售价：
350.0 元 规格：
10 mg
产品信息
概述| 货号 | 19833-10mg |
| 描述 | KIN-59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50s = 44 and 67 µM for purified E. coli and human enzymes, respectively).1,2 Through this action, KIN-59 blocks the conversion of thymidine to thymine. KIN-59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation.1,2 KIN-59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice.3 |
| 别名 | 5’-O-Tritylinosine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liekens, S.,Hernández, A.-I.,Ribatti, D., et al. The nucleoside derivative 5-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action. J.Biol.Chem. 279(28), 29598-29605 (2004).
2.Liekens, S.,Bronckaers, A.,Hernández, A.-I., et al. 5-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis. Mol.Pharmacol. 70(2), 501-509 (2006).
3.Liekens, S.,Bronckaers, A.,Belleri, M., et al. The thymidine phosphorylase inhibitor 5-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist. Mol.Cancer Ther. 11(4), 817-829 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 510.5 |
| 分子式 | C29H26N4O5 |
| CAS号 | 4152-77-6 |
| 稳定性 | ≥ 2 years |
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