HI TOPK 032
货号：
19815-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19815-1mg |
| 描述 | HI TOPK 032 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK), blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 µM and providing complete inhibition at 5 µM.1 It also inhibits checkpoint kinase 1 (Chk1; IC50 = 9.6 µM).2 In addition, HI TOPK 032 inhibits MEK1, achieving 40% inhibition at 5 µM, but it does not alter the activities of ERK1, JNK1, or p38 MAPK at 2 µM.1 HI TOPK 032 decreases the growth of colon cancer and glioma initiating cells in vitro and suppresses tumor growth in vivo.1,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, D.J.,Li, Y.,Reddy, K., et al. Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 72(12), 3060-3068 (2012).
2.Li, Y.,Kim, D.J.,Ma, W., et al. Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. J.Chem.Inf.Model 51(11), 2904-2914 (2011).
3.Joel, M.,Mughal, A.A.,Grieg, Z., et al. Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo. Mol.Cancer 14:121, (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 369.4 |
| 分子式 | C20H11N5OS |
| CAS号 | 487020-03-1 |
| 稳定性 | ≥ 2 years |
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