Inauhzin
货号：
19771-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19771-1mg |
| 描述 | Inauhzin is a cell-permeable, SIRT1 inhibitor (IC50 = 0.7-2 µM) that reactivates p53 by inhibiting SIRT1 deacetylation activity.1 It binds directly to SIRT1 and does not affect SIRT2, SIRT3, or HDAC8.1 Inauhzin has been shown to inhibit cell proliferation by inducing p53-dependent apoptosis in various human cancer cells (IC50s = 5.4, 51.9, 3.2, 33.9, and 85.4 µM for H460, H1299, A549, HT-29, and WI38 cells, respectively), as well as in xenograft tumors derived from H460 cells.1 It has also been shown to activate p53 synergistically with the Mdm2 inhibitor nutlin-3 (Item No. 10004372), sensitizing cancer cells to cisplatin (Item No. 13119) and doxorubicin (Item No. 15007).2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, Q.,Zeng, S.X.,Zhang, Y., et al. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol.Med. 4(4), 298-312 (2012).
2.Zhang, Y.,Zhang, Q.,Zeng, S.X., et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biology and Therapy 13(10), 915-924 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469.6 |
| 分子式 | C25H19N5OS2 |
| CAS号 | 309271-94-1 |
| 稳定性 | ≥ 2 years |
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