Benzbromarone
货号：
19768-500mg 基本售价：
350.0 元 规格：
500 mg
产品信息
概述| 货号 | 19768-500mg |
| 描述 | Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.1 It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.2 Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.3 |
| 别名 | MJ10061;NSC 85433; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yu, Z.,Fong, W.P., and Cheng, C.H.K. Morin (3,5,7,2,4-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Drug Metab.Dispos. 35(6), 981-986 (2007).
2.Gritsch, P.J.,Stempel, E., and Gaich, T. Enantioselective synthesis of cyclohepta[b]indoles: Gram-scale synthesis of (S)-SIRT1-inhibitor IV. Organic Letters (2013).
3.Rettie, A.E., and Jones, J.P. Clinical and toxicological relevance of CYP2C9: Drug-drug interactions and pharmacogenetics. Annual Reviews of Pharmacology and Toxicology 45, 477-494 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 424.1 |
| 分子式 | C17H12Br2O3 |
| CAS号 | 3562-84-3 |
| 稳定性 | ≥ 2 years |
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