NCT-503
货号：
19718-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19718-1mg |
| 描述 | NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM.1 It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pacold, M.E.,Brimacombe, K.R.,Chan, S.H., et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology 12(6), 452-458 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 408.5 |
| 分子式 | C20H23F3N4S |
| CAS号 | 1916571-90-8 |
| 稳定性 | ≥ 1 year |
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