Bleomycin A5 (hydrochloride)
货号：
19692-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19692-1mg |
| 描述 | Bleomycin A5 is one of a family of glycopeptide antibiotics first isolated from S. verticillus. As a family, the bleomycins consist of carbohydrate and metal binding domains joined to a variable C-terminal tail through a linker domain.1,2 The metal binding domain and C-terminal tail mediate DNA and RNA binding that, in the presence of oxygen, generates free radicals leading to nucleic acid cleavage.1,2 Bleomycin A5 has a C-terminal that mimics polyamines, facilitating its import into cells via the carnitine transporter SLC22A16.3 Cells expressing this transporter are ~300-fold more sensitive to bleomycin A5 than cells lacking this transporter, suggesting that cancer cells that overexpress SCL22A16 might be selectively targeted by this form of bleomycin.3 |
| 别名 | Pingyangmycin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hecht, S.M. Bleomycin: New perspectives on the mechanism of action. Journal of Natural Products 63, 158-168 (2000).
2.Palwai, V.R., and Eriksson, L.A. Molecular dynamics simulations exploring the interaction between DNA and metalated bleomycin. J. Biophys. Chem. 2(2), 170-182 (2011).
3.Aouida, M.,Poulin, R., and Ramotar, D. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. The Journal of Biological Chemisty 285(9), 6275-6284 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥85% |
| 计算分子量 | 1477 |
| 分子式 | C57H89N19O21S2 • XHCl |
| CAS号 | 55658-47-4 |
| 稳定性 | ≥ 2 years |
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