L-748,337
货号：
19643-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19643-1mg |
| 描述 | L-748,337 is a β3-adrenergic receptor antagonist that displays selectivity over β1 and β2 receptors (Kis = 4, 390, and 204 nM, respectively).1 It has been shown to couple with Gi to activate MAPK signaling.2 L-748,337 can inhibit agonist-stimulated lipolysis in rhesus monkey adipocytes, as well as agonist-induced relaxation of smooth muscle.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Candelmore, M.R.,Deng, L.,Tota, L., et al. Potent and selective human β3-adrenergic receptor antagonists. J. Pharmacol. Exp. Ther. 290(2), 649-655 (1999).
2.Sato, M.,Hutchinson, D.S.,Evans, B.A., et al. The β3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human β3-adrenoceptor. Molecular Pharmacology 74(5), 1417-1428 (2008).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 497.6 |
| 分子式 | C26H31N3O5S |
| CAS号 | 244192-94-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
