| 货号 | 19639-1mg |
| 描述 | Argatroban is a reversible, competitive thrombin inhibitor (Ki = 5 nM) that shows selectivity for thrombin over other clotting pathway enzymes.1,2,3 It inhibits thrombin bound to fibrin clots as well as thrombin that is free in solution.1 This direct thrombin inhibitor prevents or alleviates thrombosis in cases of heparin-induced thrombocytopenia.4 |
| 别名 | MCI-9038; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hantgan, R.R.,Jerome, W.G., and Hursting, M.J. No effect of clot age or thrombolysis on argatroban’s inhibition of thrombin. Blood 92(6), 2064-2074 (1998). 2.Park, H.D.,Lee, S.H.,Kim, T.H., et al. Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug. Bioorganic & Medicinal Chemistry Letters 23(17), 4779-4784 (2013). 3.Tapparelli, C.,Metternich, R.,Ehrhardt, C., et al. In vitro and in vivo characterization of a neutral boron-containing thrombin inhibitor. The Journal of Biological Chemisty 268(7), 4734-4741 (1993). 4.Coppens, M.,Eikelboom, J.W.,Gustafsson, D., et al. Translational success stories: Development of direct thrombin inhibitors. Circulation Research 111(7), 920-929 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 508.6 |
| 分子式 | C23H36N6O5S |
| CAS号 | 74863-84-6 |
| 稳定性 | ≥ 2 years |
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