| 货号 | 19638-1mg |
| 描述 | 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is a natural ITC first isolated from wasabi (W. japonica). It has diverse effects on intracellular signaling, gene expression, and cell cycling in different types of cells in culture. These include inhibiting the growth of cancer cells, blocking inflammatory signaling in leukocytes, altering platelet aggregation, and inducing anti-inflammatory and anti-oxidant genes.1,2,3,4 6-MSITC also demonstrates neuroprotective effects in a mouse model of Parkinson’s disease.5 |
| 别名 | 6-MSITC; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Noshita, T.,Kidachi, Y.,Funayama, H., et al. Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity. European Journal of Medicinal Chemistry 44(12), 4931-4936 (2009). 2.Morimitsu, Y.,Hayashi, K.,Nakagawa, Y., et al. Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi. Mech.Ageing Dev. 116(203), 125-134 (2000). 3.Hou, D.X.,Fukuda, M.,Fujii, M., et al. Transcriptional regulation of nicotinamide adenine dinucleotide phosphate: Quinone oxidoreductase in murine hepatoma cells by 6-(methylsufinyl)hexyl isothiocyanate, an active principle of wasabi (Eutrema wasabi Maxim). Cancer Letters 161(2), 195-200 (2000). 4.Chen, J.,Uto, T.,Tanigawa, S., et al. Microarray-based determination of anti-inflammatory genes targeted by 6-(methylsulfinyl)hexyl isothiocyanate in macrophages. Exp.Ther.Med. 1(1), 33-40 (2010). 5.Morroni, F.,Sita, G.,Tarozzi, A., et al. Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson’s disease. Brain Research 1589, 93-104 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 205.3 |
| 分子式 | C8H15NOS2 |
| CAS号 | 4430-35-7 |
| 稳定性 | ≥ 1 year |
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