| 货号 | 19628-1mg |
| 描述 | GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7; EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM).1 It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood mononuclear cells.2,3,4 |
| 别名 | Vesatolimod; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Turnas, P.,Zheng, X.,Lu, B., et al. Preclinical characterization of GS-9620, a potent and selective oral TLR7 agonist. J. Hepatol. 54, S446-S447 (2011). 2.Menne, S.,Tumas, D.B.,Liu, K.H., et al. Sustained efficacy and seroconversion with the toll-like receptor 7 agonist GS-9620 in the woodchuck model of chronic hepatitis B. J. Hepatol. 62(6), 1237-1245 (2015). 3.Lanford, R.E.,Guerra, B.,Chavez, D., et al. GS-9620, an oral agonist of toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology 144(7), 1508-1517 (2013). 4.Bam, R.A.,Hansen, D.,Irrinki, A., et al. TLR7 agonist GS-9620 is a potent inhibitor of acute HIV-1 infection in human peripheral blood mononuclear cells. Antimicrob. Agents Chemother. [Epub ahead of print], 1-42 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 410.5 |
| 分子式 | C22H30N6O2 |
| CAS号 | 1228585-88-3 |
| 稳定性 | ≥ 2 years |
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