INK1117
货号：
19514-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19514-1mg |
| 描述 | INK1117 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro(IC50 = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR) and in cells when used at 1 µM.1,2 It blocks signaling to Akt and inhibits growth of cancer cells harboring wild-type or mutated p110α.1 INK1117 does not interfere with B cell proliferation or NK cell maturation and survival.1,2 |
| 别名 | MLN1117;TAK-117; |
性能| 供应商 | Cayman |
| 应用文献 |
1.So, L.,Yea, S.S.,Oak, J.S., et al. Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function. The Journal of Biological Chemisty 288(8), 5718-5731 (2013).
2.Yea, S.S.,So, L.,Mallya, S., et al. Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. PLoS One 9(6), (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 363.4 |
| 分子式 | C19H17N5O3 |
| CAS号 | 1268454-23-4 |
| 稳定性 | ≥ 2 years |
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