VX-509
货号：
19513-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19513-1mg |
| 描述 | VX-509 is a selective inhibitor of Janus kinase 3 (JAK3) with a Ki value of 2.5 nM in enzyme assays and an IC50 value of 50-170 nM in cellular assays dependent on JAK3 activity with no measurable activity against other JAK isotypes.1 At 10-100 mg/kg, it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.1 |
| 别名 | Decernotinib;VRT-831509; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mahajan, S.,Hogan, J.K.,Shlyakhter, D., et al. VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease. Journal of Pharmacology and Experimental Therapeutics 353(2), 405-414 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 392.4 |
| 分子式 | C18H19F3N6O |
| CAS号 | 944842-54-0 |
| 稳定性 | ≥ 2 years |
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