CWHM12
货号：
19480-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19480-1mg |
| 描述 | CWHM12 is an analog of RGD peptide (Item No. 14501), a tripeptide that inhibits integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.1 CWHM12 selectively inhibits αv integrins (IC50s = 1.8, 0.8, 61, 1.5, and 0.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, and αvβ8, respectively) over αIIbβ3, α2β1, and α10β1.2 CWHM 12 attenuates liver, lung, and pancreatic fibrosis in mice treated with CCl4 or cerulein.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ruoslahti, E., and Öbrink, B. Common principles in cell adhesion. Experimental Cell Research 227, 1-11 (1996).
2.Henderson, N.C.,Arnold, T.D.,Katamura, Y., et al. Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs. Nat. Med. 19(12), 1-12 (2013).
3.Ulmasov, B.,Newschwander-Tetri, B.A.,Lai, J., et al. Inhibitors of Arg-Gly-Asp-binding integrins reduce development of pancreatic fibrosis in mice. Cell. Mol. Gastroenterol. Hepatol. 2(4), 499-518 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 590.5 |
| 分子式 | C26H32BrN5O6 |
| CAS号 | 1564286-55-0 |
| 稳定性 | ≥ 2 years |
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