| 货号 | 19421-1mg |
| 描述 | BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively).1 It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ross-Macdonald, P.,de Silva, H.,Guo, Q., et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol. Cancer Ther. 7(11), 3490-3498 (2008). 2.Li, X.,Zhu, Y.,Cao, Y., et al. LIM kinase activity is required for microtubule organising centre positioning in mouse oocyte meiosis. Reprod. Fertil. Dev. (2016). 3.Romarowski, A.,Battistone, M.A.,La Spina, F.A., et al. PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis. Dev. Biol. 405(2), 237-249 (2015). 4.Sari-Hassoun, M.,Clement, M.-J.,Hamdi, I., et al. Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase. Biochem. Pharmacol. 102, 45-63 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 429.3 |
| 分子式 | C17H12Cl2F2N4OS |
| CAS号 | 1338247-30-5 |
| 稳定性 | ≥ 3 years |
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