CC-115
货号：
19420-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19420-1mg |
| 描述 | CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC50s = 22 and 15 nM, respectively).1 CC-115 reduces PC3 cancer cell growth in vitro(IC50 = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts (mEC50 = 1 mg/kg). In a Phase I clinical trial, formulations containing CC-115 reduced lymph node sizes in almost all patients with chronic lymphocytic leukemia (CLL) that also have ataxia telangiectasia mutated (ATM) kinase deletions.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mortensen, D.S.,Perrin-Ninkovic, S.M.,Shevlin, G., et al. Optimization of a series of triazole containing mammalian target of rapamycin (mTOR) kinase inhibitors and the discovery of CC-115. J. Med. Chem. 58(14), 5599-5608 (2015).
2.Thijssen, R.,tter Burg, J.,Garrick, B., et al. Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. Blood 128(4), 574-583 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 336.4 |
| 分子式 | C16H16N8O |
| CAS号 | 1228013-15-7 |
| 稳定性 | ≥ 2 years |
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