DC260126
货号：
19388-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19388-1mg |
| 描述 | DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150,90260,10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 µM, respectively.1 At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/dbmice.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hu, H.,He, L.y.,Gong, Z., et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem.Bioph.Res.Commun. 390(3), 557-563 (2009).
2.Sun, T.,Wang, T.,Zhou, Y., et al. DC260126: A small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS One 8(6), (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 307.4 |
| 分子式 | C16H18FNO2S |
| CAS号 | 346692-04-4 |
| 稳定性 | ≥ 2 years |
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