Ceritinib
货号：
19374-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19374-1mg |
| 描述 | Ceritinib is an inhibitor of anaplastic lymphoma kinase (ALK) with an IC50 value of 200 pM in ALK enzymatic assays.1,2 It less potently inhibits IGF-1R, InsR, and STK22D (IC50s = 8, 7, and 23 nM, respectively), and is minimally effective against a panel of other kinases. Ceritinib inhibits ALK in cells (IC50 = 25 nM) and in vivo, producing tumor regression in a rat xenograft model.1 It is also effective against several crizotinib-resistant mutants of ALK.3 |
| 别名 | LDK 378; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Awad, M.M., and Shaw, A.T. ALK inhibitors in non-small cell lung cancer: Crizotinib and beyond. Clin. Adv. Hematol. Oncol. 12(7), 429-439 (2014).
2.Sullivan, I., and Planchard, D. ALK inhibitors in non-small cell lung cancer: The latest evidence and developments. Ther.Adv.Med.Oncol. 8(1), 32-47 (2016).
3.Fontana, D.,Ceccon, M.,Gambacorti-Passerini, C., et al. Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK. Cancer Med. 4(7), 953-965 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 558.1 |
| 分子式 | C28H36ClN5O3S |
| CAS号 | 1032900-25-6 |
| 稳定性 | ≥ 2 years |
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