| 货号 | 19286-1g |
| 描述 | Esculetin is a natural plant phenolic that shares features of coumarins and catechols. It inhibits lipoxygenases (LOs), including 5-LO and 12-LO (ID50s = 4 and 2.5 µM, respectively).1 This action is likely due to its ability to bind iron, as it also inhibits other iron-containing enzymes, including the lysine-specific demethylase KDM5B.2,3 Like other coumarins, esculetin promotes TRAIL-induced apoptosis in cancer cells.4 Esculetin is also used as an antioxidant to reduce reactive oxygen species and modulate oxidant-sensitive enzymes.5 Esculetin, which can be derived from esculin by β-glucosidases, also has anti-fungal activities.6 |
| 别名 | Aesculetin;Cichorigenin;6,7-Dihydroxycoumarin;NSC 26427; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Neichi, T.,Koshihara, Y., and Murota, S.I. Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis. Biochimica et Biophysica Acta 753, 130-132 (1983). 2.Clemens, S., and weber, M. The essential role of coumarin secretion for Fe acquisition from alkaline soil. Plant Signal.Behav. 11(2), (2016). 3.Sayegh, J.,Cao, J.,Zou, M.R., et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. The Journal of Biological Chemisty 288(13), 9408-9417 (2013). 4.Rana, A.,Attar, R.,Qureshi, M.Z., et al. Dealing naturally with stumbling blocks on highways and byways of TRAIL induced signaling. Asian Pac.J.Cancer Prev. 15(19), 8041-8046 (2014). 5.Angeles, D.C.,Ho, P.,Dymock, B.W., et al. Antioxidants inhibit neuronal toxicity in Parkinson’s disease-linked LRRK2. Ann. Clin. Transl. Neurol. 3(4), 288-294 (2016). 6.Mercer, D.K.,Robertson, J.,Wright, K., et al. A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PloS One 8(11), (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 178.1 |
| 分子式 | C9H6O4 |
| CAS号 | 305-01-1 |
| 稳定性 | ≥ 2 years |
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