| 货号 | 19284-1mg |
| 描述 | BPTES is an inhibitor of kidney-type glutaminase 1 (GLS1; IC50 = 3.3 μM) that drives the formation of inactive tetramers.1,2,3 It is selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase. Through its effects on GLS1, BPTES increases the production of reactive oxygen species and reduces ATP levels in hypoxic cells, induces cell death of P493 human lymphoma B cells in vitro, and delays tumor xenograft growth in vivo.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.DeLaBarre, B.,Gross, S.,Fang, C., et al. Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50(50), 10764-10770 (2011). 2.Robinson, M.M.,McBryant, S.J.,Tsukamoto, T., et al. Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES). Biochem J. 406(3), 407-414 (2007). 3.Shukla, K.,Feraris, D.V.,Thomas, A.G., et al. Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J. Med. Chem. 55(23), 10551-10563 (2012). 4.Le, A.,Lane, A.N.,Hamaker, M., et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell. Metab. 15(1), 110-121 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 524.7 |
| 分子式 | C24H24N6O2S3 |
| CAS号 | 314045-39-1 |
| 稳定性 | ≥ 2 years |
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