| 货号 | 19262-500mg |
| 描述 | Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.1 It displays high affinity for liver fatty acid binding protein (Ki = 24 nM).2 Fenofibric acid increases plasma apolipoprotein A-II via the response element for peroxisome proliferator-activated receptors (PPARs), although it has very low affinity for PPARs (IC50s > 100 µM for both human PPARα or PPARγ).3,1 However, in a transactivation assay, it exhibits EC50 values of 18 and 30 µM for mosue and human PPARα, respectively.4 Fenofibric acid, when combined with statins, has been shown to be effective against mixed dyslipidemia in clinical trials.5 |
| 别名 | FNF Acid;NSC 281318; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mukherjee, R.,Locke, K.T.,Miao, B., et al. Novel peroxisome proliferator-activated receptor α agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. Journal of Pharmacology and Experimental Therapeutics 327(3), 716-726 (2008). 2.Chuang, S.,Velkov, T.,Horne, J., et al. Characterization of the drug binding specificity of rat liver fatty acid binding protein. Journal of Medicinal Chemistry 51(13), 3755-3764 (2008). 3.Vu-Dac, N.,Schoonjans, K.,Kosykh, V., et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. Journal of Clinical Investigation 96(2), 741-750 (1995). 4.Willson, T.M.,Brown, P.J.,Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. Journal of Medicinal Chemistry 43(4), 528-550 (2000). 5.Alagona, P., Jr. Fenofibric acid: A new fibrate approved for use in combination with statin for the treatment of mixed dyslipidemia. Vascular Health and Risk Management 6, 351-362 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 318.8 |
| 分子式 | C17H15ClO4 |
| CAS号 | 42017-89-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |