Tanomastat
货号：
19258-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 19258-500ug |
| 描述 | Tanomastat is an orally available, non-peptidic inhibitor of matrix metalloproteinase-2 (MMP-2), MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively).1 It is active in various animal models of tumor metastasis and has been used in a phase III clinical trial in pancreatic, SCLC, NSCLC, and ovarian cancer patients.2,3 |
| 别名 | BAY 12-9566; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Leung, D.,Abbenante, G., and Fairlie, D.P. Protease inhibitors: Current status and future prospects. J. Med. Chem. 43(3), 305-341 (2000).
2.Rowinsky, E.K.,Humphrey, R.,Hammond, L.A., et al. Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies. Journal of Clinical Oncology 18(1), 178-186 (2000).
3.Chaudhary, A.K.,Pandya, S.,Ghosh, K., et al. Matrix metalloproteinase and its drug targets therapy in solid and hematological malignancies: An overview. Mutation Research 753(1), 7-23 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 410.9 |
| 分子式 | C23H19ClO3S |
| CAS号 | 179545-77-8 |
| 稳定性 | ≥ 2 years |
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