CBR-5884
货号：
19236-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19236-1mg |
| 描述 | CBR-5884 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 33 µM.1 It does not affect other NAD+-dependent dehydrogenases, including lactate dehydrogenase and malate dehydrogenase 1. CBR-5884 inhibits the proliferation of cancer cells by blocking de novo serine synthesis and is selectively cytotoxic for cells with high serine biosynthetic activity.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mullarky, E.,Lucki, N.C.,Zavareh, R.B., et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America 113(7), 1778-1783 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 336.4 |
| 分子式 | C14H12N2O4S2 |
| CAS号 | 681159-27-3 |
| 稳定性 | ≥ 2 years |
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