| 货号 | 19205-1mg |
| 描述 | VAS2870 is a selective inhibitor of the NADPH oxidases.1,2,3,4 Pre-incubation of rat vascular smooth muscle cells with VAS2870 abolishes platelet-derived growth factor-dependent chemotaxis without affecting cell-cycle progression (IC50 = 10 µM).1 At low (2.8 mM), but not high (16.7 mM), concentrations of glucose, treatment with VAS2870 (20 µM) increases glucose-stimulated insulin secretion of rat pancreatic islets by 70%.5 It significantly reduces production of reactive oxygen species in mouse brain, rat vascular smooth muscle culture, and human umbilical vein endothelial cells.1,6,7 Treatment with VAS2870 pre- or post-ischemia is neuroprotective in mouse brain.6 VAS2870 inhibits vasculogenesis of mouse embryonic stem cell cultures and inhibits cell proliferation of rat hepatoma cells.8,9 |
| 别名 | BML-EI95; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.ten Freyhaus, H.,Huntgeburth, M.,Wingler, K., et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc. Res. 71(2), 331-341 (2006). 2.Altenhöfer, S.,Kleikers, P.W.M.,Radermacher, K.A., et al. The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell. Mol. Life Sci. 69(14), 2327-2343 (2012). 3.Wingler, K.,Altenhofer, S.A.,Kleikers, P.W.M., et al. VAS2870 is a pan-NADPH oxidase inhibitor. Cell. Mol. Life Sci. 69(18), 3159-3160 (2012). 4.Wind, S.,Beuerlein, K.,Eucker, T., et al. Comparative pharmacology of chemically distinct NADPH oxidase inhibitors. Br. J. Pharmacol. 161(4), 885-898 (2010). 5.Munhoz, A.C.,Riva, P.,Simões, D., et al. Control of insulin secretion by production of reactive oxygen species: Study performed in pancreatic islets from fed and 48-hour fasted Wistar rats. PLoS One 11(6), e0158166 (2016). 6.Kleinschnitz, C.,Grund, H.,Wingler, K., et al. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS One 8(9), e1000479 (2010). 7.Stielow, C.,Catar, R.A.,Muller, G., et al. Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem. Biophys. Res. Commun. 344(1), 200-205 (2006). 8.Lange, S.,Heger, J.,Euler, G., et al. Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species. Cardiovasc. Res. 81(1), 159-168 (2009). 9.Sancho, P., and Fabregat, I. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cell. Biochem. Pharmacol. 81(7), 917-924 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.4 |
| 分子式 | C18H12N6OS |
| CAS号 | 722456-31-7 |
| 稳定性 | ≥ 2 years |
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