Statil
货号：
19189-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 19189-5mg |
| 描述 | Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively.1 Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats.2 Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.3 |
| 别名 | ICI 128436;MK-538;Ponalrestat; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ward, W.H.J.,Sennitt, C.M.,Ross, H., et al. Ponalrestat: A potent and specific inhibitor of aldose reductase. Biochemical Pharmacology 39(2), 337-346 (1990).
2.Otter, D.J., and Chess-Williams, R. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. British Journal of Pharmacology 113(2), 576-580 (1994).
3.Michaud, A.,Lacroix-Pépin, N.,Pelletier, M., et al. Prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue: Modulation by inflammatory cytokines and role of the human aldose reductase AKR1B. PLoS One 9(3), (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 391.2 |
| 分子式 | C17H12BrFN2O3 |
| CAS号 | 72702-95-5 |
| 稳定性 | ≥ 2 years |
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