| 货号 | 19181-500ug |
| 描述 | MLCK inhibitor peptide 18 is a cell-permeable inhibitor of myosin light chain kinase (MLCK; IC50 = 50 nM) with 4,000-fold selectivity for MLCK over CaM kinase II and PKA.1,2 It prevents defects in transepithelial barrier resistance induced by bacteria or TNF-α plus IFN-γ.2 MLCK inhibitor peptide 18 prevents sperm chromatin-induced cortical reorganization in mouse oocytes and decreases phagocytosis of C3bi-opsonized and non-opsonized myelin by primary mouse microglia.3,4 |
| 别名 | Myosin Light Chain Kinase Inhibitor Peptide 18; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lukas, T.J.,Mirzoeva, S.,Slomczynska, U., et al. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. Journal of Medicinal Chemistry 42(5), 910-919 (1999). 2.Zolotarevsky, Y.,Hecht, G.,Koutsouris, A., et al. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123(1), 163-172 (2002). 3.Deng, M.,Williams, C.J., and Schultz, R.M. Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity. Dev.Biol. 278(2), 358-366 (2005). 4.Gitik, M.,Reichert, F., and Rotschenker, S. Cytoskeleton plays a dual role of activation and inhibition in myelin and zymosan phagocytosis by microglia. The FASEB Journal 24(7), 2211-2221 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1324.6 |
| 分子式 | C60H105N23O11 |
| CAS号 | 224579-74-2 |
| 稳定性 | ≥ 2 years |
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